The Tampa Bay Region is home to two of the state's most populous cities: Tampa  and  St. Petersburg. This region has become a hotspot for high-tech company growth. It anchors one end of the Florida High Tech Corridor, which houses more than 50% of Florida ’s high-tech companies.

Infrastructure: Tampa Bay offers the right infrastructure needed for firms to quickly and effectively move products, services and data. With multiple seaports and airports, it is a major entry point for domestic and international shipping. In addition, the region is continuously updating its interstate and highway infrastructure.

Industry: Home to multiple universities and colleges with prime research facilities, Tampa Bay’s industry clusters range from life sciences and healthcare to homeland security, avionics and marine electronics. Tampa Bay has also been called "Wall Street South" for the size and scope of its financial services industry.

Workforce:  Comprised of about 2 million professionals, the Tampa region is rich in talent. University of South Florida (USF) and local colleges collaborate with companies in the development of products and services and thus are able to graduate students that are equipped with the most practical, industry-relevant skills and knowledge. Thus, local employers enjoy a consistent supply of well-educated and ambitious professionals.

Quality of Life: Tampa Bay offers a competitive cost of living and some of the best healthcare facilities in the United States, including several hospitals ranked as "America's Best Hospitals" by U.S. News and World Report. It has a clear urban appeal with major metropolitan newspapers, one of the largest performing arts centers in the southeast, and the largest science museum in the south.

The Tampa Bay Region MSAs include Tampa-St. Petersburg-Clearwater, Bradenton-Sarasota-Venice, and Lakeland-Winter Haven.